Neutrophil cytosol factor 2 (NCF2)

About Neutrophil cytosol factor 2

Neutrophil cytosol factor 2 (NCF2) is a protein from Homo sapiens identified by UniProt accession P19878, 526 residues long. MolForge cross-references it against 0 known binders and 320 disease associations.

Target properties

Protein name	Neutrophil cytosol factor 2
UniProt accession	P19878
Gene	NCF2
Organism	Homo sapiens
Length	526 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (320)

Diseases linked to this target (Open Targets).

chronic granulomatous disease · score 0.67
systemic lupus erythematosus · score 0.46
neutrophil count · score 0.34
total blood protein measurement · score 0.29
breast adenocarcinoma · score 0.25
rheumatoid arthritis · score 0.21
celiac disease · score 0.21
eosinophil count · score 0.21
neutrophil percentage of leukocytes · score 0.21
genetic disorder · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P19878-F1	alphafold	PREDICTED	78.54	—

Amino-acid sequence (526 residues)

MSLVEAISLW NEGVLAADKK DWKGALDAFS AVQDPHSRIC FNIGCMYTIL KNMTEAEKAF TRSINRDKHL AVAYFQRGML YYQTEKYDLA IKDLKEALIQ LRGNQLIDYK ILGLQFKLFA CEVLYNIAFM YAKKEEWKKA EEQLALATSM KSEPRHSKID KAMECVWKQK LYEPVVIPVG KLFRPNERQV AQLAKKDYLG KATVVASVVD QDSFSGFAPL QPQAAEPPPR PKTPEIFRAL EGEAHRVLFG FVPETKEELQ VMPGNIVFVL KKGNDNWATV MFNGQKGLVP CNYLEPVELR IHPQQQPQEE SSPQSDIPAP PSSKAPGRPQ LSPGQKQKEE PKEVKLSVPM PYTLKVHYKY TVVMKTQPGL PYSQVRDMVS KKLELRLEHT KLSYRPRDSN ELVPLSEDSM KDAWGQVKNY CLTLWCENTV GDQGFPDEPK ESEKADANNQ TTEPQLKKGS QVEALFSYEA TQPEDLEFQE GDIILVLSKV NEEWLEGECK GKVGIFPKVF VEDCATTDLE STRREV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards