Follistatin (FST)

About Follistatin

Follistatin (FST) is a protein from Homo sapiens identified by UniProt accession P19883, 344 residues long. MolForge cross-references it against 0 known binders and 520 disease associations.

Target properties

Protein name	Follistatin
UniProt accession	P19883
Gene	FST
Organism	Homo sapiens
Length	344 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (520)

Diseases linked to this target (Open Targets).

self reported educational attainment · score 0.44
urate measurement · score 0.40
glomerular filtration rate · score 0.38
appendicular lean mass · score 0.37
neurodegenerative disease · score 0.36
high density lipoprotein cholesterol measurement · score 0.35
body height · score 0.34
serum gamma-glutamyl transferase measurement · score 0.33
follistatin measurement · score 0.33
C-reactive protein measurement · score 0.32

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P19883-F1	alphafold	PREDICTED	88.38	—

Amino-acid sequence (344 residues)

MVRARHQPGG LCLLLLLLCQ FMEDRSAQAG NCWLRQAKNG RCQVLYKTEL SKEECCSTGR LSTSWTEEDV NDNTLFKWMI FNGGAPNCIP CKETCENVDC GPGKKCRMNK KNKPRCVCAP DCSNITWKGP VCGLDGKTYR NECALLKARC KEQPELEVQY QGRCKKTCRD VFCPGSSTCV VDQTNNAYCV TCNRICPEPA SSEQYLCGND GVTYSSACHL RKATCLLGRS IGLAYEGKCI KAKSCEDIQC TGGKKCLWDF KVGRGRCSLC DELCPDSKSD EPVCASDNAT YASECAMKEA ACSSGVLLEV KHSGSCNSIS EDTEEEEEDE DQDYSFPISS ILEW

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards