Alpha-amylase 2B (AMY2B)

About Alpha-amylase 2B

Alpha-amylase 2B (AMY2B) is a protein from Homo sapiens identified by UniProt accession P19961, 511 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.

Target properties

Protein name	Alpha-amylase 2B
UniProt accession	P19961
Gene	AMY2B
Organism	Homo sapiens
Length	511 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (32)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.39
dentures · score 0.23
lung adenocarcinoma · score 0.18
squamous cell lung carcinoma · score 0.18
head and neck squamous cell carcinoma · score 0.18
cutaneous melanoma · score 0.18
endometrial cancer · score 0.18
dental caries · score 0.18
esophageal cancer · score 0.11
diabetes mellitus · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P19961-F1	alphafold	PREDICTED	96.77	—

Amino-acid sequence (511 residues)

MKFFLLLFTI GFCWAQYSPN TQQGRTSIVH LFEWRWVDIA LECERYLAPK GFGGVQVSPP NENVAIHNPF RPWWERYQPV SYKLCTRSGN EDEFRNMVTR CNNVGVRIYV DAVINHMSGN AVSAGTSSTC GSYFNPGSRD FPAVPYSGWD FNDGKCKTGS GDIENYNDAT QVRDCRLVGL LDLALEKDYV RSKIAEYMNH LIDIGVAGFR LDASKHMWPG DIKAILDKLH NLNSNWFPAG SKPFIYQEVI DLGGEPIKSS DYFGNGRVTE FKYGAKLGTV IRKWNGEKMS YLKNWGEGWG FMPSDRALVF VDNHDNQRGH GAGGASILTF WDARLYKMAV GFMLAHPYGF TRVMSSYRWP RQFQNGNDVN DWVGPPNNNG VIKEVTINPD TTCGNDWVCE HRWRQIRNMV NFRNVVDGQP FTNWYDNGSN QVAFGRGNRG FIVFNNDDWT FSLTLQTGLP AGTYCDVISG DKINGNCTGI KIYVSDDGKA HFSISNSAED PFIAIHAESK L

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards