About Transcobalamin-1
Transcobalamin-1 (TCN1) is a protein
from Homo sapiens identified by UniProt accession
P20061, 433 residues long.
MolForge cross-references it against 0 known binders and
161 disease associations.
Target properties
| Protein name | Transcobalamin-1 |
|---|
| UniProt accession | P20061 |
|---|
| Gene | TCN1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 433 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (161)
Diseases linked to this target (Open Targets).
- transcobalamin I deficiency · score 0.51
- vitamin B12 measurement · score 0.43
- blood protein measurement · score 0.33
- pernicious anemia · score 0.31
- neuroinflammatory disorder · score 0.20
- head and neck squamous cell carcinoma · score 0.13
- psoriasis · score 0.08
- lung adenocarcinoma · score 0.08
- neoplasm · score 0.07
- ulcerative colitis · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P20061-F1 | alphafold | PREDICTED | 89.13 | — |
Amino-acid sequence (433 residues)
MRQSHQLPLV GLLLFSFIPS QLCEICEVSE ENYIRLKPLL NTMIQSNYNR GTSAVNVVLS LKLVGIQIQT LMQKMIQQIK YNVKSRLSDV SSGELALIIL ALGVCRNAEE NLIYDYHLID KLENKFQAEI ENMEAHNGTP LTNYYQLSLD VLALCLFNGN YSTAEVVNHF TPENKNYYFG SQFSVDTGAM AVLALTCVKK SLINGQIKAD EGSLKNISIY TKSLVEKILS EKKENGLIGN TFSTGEAMQA LFVSSDYYNE NDWNCQQTLN TVLTEISQGA FSNPNAAAQV LPALMGKTFL DINKDSSCVS ASGNFNISAD EPITVTPPDS QSYISVNYSV RINETYFTNV TVLNGSVFLS VMEKAQKMND TIFGFTMEER SWGPYITCIQ GLCANNNDRT YWELLSGGEP LSQGAGSYVV RNGENLEVRW SKY
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