L-serine dehydratase/L-threonine deaminase (SDS)

About L-serine dehydratase/L-threonine deaminase

L-serine dehydratase/L-threonine deaminase (SDS) is a protein from Homo sapiens identified by UniProt accession P20132, 328 residues long. MolForge cross-references it against 0 known binders and 49 disease associations.

Target properties

Protein name	L-serine dehydratase/L-threonine deaminase
UniProt accession	P20132
Gene	SDS
Organism	Homo sapiens
Length	328 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (49)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
body mass index · score 0.14
blood protein measurement · score 0.13
diabetic ketoacidosis · score 0.13
smoking behavior · score 0.08
cerebrospinal fluid biomarker measurement · score 0.06
hepatocellular carcinoma · score 0.05
esophageal adenocarcinoma · score 0.04
type 2 diabetes mellitus · score 0.03
erosive tooth wear measurement · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P20132-F1	alphafold	PREDICTED	95.88	—

Amino-acid sequence (328 residues)

MMSGEPLHVK TPIRDSMALS KMAGTSVYLK MDSAQPSGSF KIRGIGHFCK RWAKQGCAHF VCSSAGNAGM AAAYAARQLG VPATIVVPST TPALTIERLK NEGATVKVVG ELLDEAFELA KALAKNNPGW VYIPPFDDPL IWEGHASIVK ELKETLWEKP GAIALSVGGG GLLCGVVQGL QEVGWGDVPV IAMETFGAHS FHAATTAGKL VSLPKITSVA KALGVKTVGA QALKLFQEHP IFSEVISDQE AVAAIEKFVD DEKILVEPAC GAALAAVYSH VIQKLQLEGN LRTPLPSLVV IVCGGSNISL AQLRALKEQL GMTNRLPK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards