TATA-box-binding protein (TBP)

About TATA-box-binding protein

TATA-box-binding protein (TBP) is a protein from Homo sapiens identified by UniProt accession P20226, 339 residues long. MolForge cross-references it against 0 known binders and 295 disease associations.

Target properties

Protein name	TATA-box-binding protein
UniProt accession	P20226
Gene	TBP
Organism	Homo sapiens
Length	339 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (295)

Diseases linked to this target (Open Targets).

spinocerebellar ataxia type 17 · score 0.60
HIV infection · score 0.58
neurodegenerative disease · score 0.33
breast adenocarcinoma · score 0.25
glioblastoma multiforme · score 0.25
blood protein measurement · score 0.25
protein measurement · score 0.23
Parkinson disease · score 0.19
head and neck squamous cell carcinoma · score 0.19
genetic disorder · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P20226-F1	alphafold	PREDICTED	77.13	—

Amino-acid sequence (339 residues)

MDQNNSLPPY AQGLASPQGA MTPGIPIFSP MMPYGTGLTP QPIQNTNSLS ILEEQQRQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQAVAAA AVQQSTSQQA TQGTSGQAPQ LFHSQTLTTA PLPGTTPLYP SPMTPMTPIT PATPASESSG IVPQLQNIVS TVNLGCKLDL KTIALRARNA EYNPKRFAAV IMRIREPRTT ALIFSSGKMV CTGAKSEEQS RLAARKYARV VQKLGFPAKF LDFKIQNMVG SCDVKFPIRL EGLVLTHQQF SSYEPELFPG LIYRMIKPRI VLLIFVSGKV VLTGAKVRAE IYEAFENIYP ILKGFRKTT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards