About Tryptase beta-2
Tryptase beta-2 (TPSB2) is a protein
from Homo sapiens identified by UniProt accession
P20231, 275 residues long.
MolForge cross-references it against 0 known binders and
84 disease associations.
Target properties
| Protein name | Tryptase beta-2 |
|---|
| UniProt accession | P20231 |
|---|
| Gene | TPSB2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 275 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (84)
Diseases linked to this target (Open Targets).
- urticaria · score 0.23
- appendicular lean mass · score 0.16
- blood protein measurement · score 0.14
- tryptase beta-2 measurement · score 0.12
- Immunodeficiency due to a late component of complements deficiency · score 0.09
- DNA methylation · score 0.08
- fat body mass · score 0.07
- immunodeficiency 28 · score 0.07
- varicella, severe recurrent · score 0.07
- systemic mastocytosis · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P20231-F1 | alphafold | PREDICTED | 91.30 | — |
Amino-acid sequence (275 residues)
MLNLLLLALP VLASRAYAAP APGQALQRVG IVGGQEAPRS KWPWQVSLRV RDRYWMHFCG GSLIHPQWVL TAAHCVGPDV KDLAALRVQL REQHLYYQDQ LLPVSRIIVH PQFYTAQIGA DIALLELEEP VNVSSHVHTV TLPPASETFP PGMPCWVTGW GDVDNDERLP PPFPLKQVKV PIMENHICDA KYHLGAYTGD DVRIVRDDML CAGNTRRDSC QGDSGGPLVC KVNGTWLQAG VVSWGEGCAQ PNRPGIYTRV TYYLDWIHHY VPKKP
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