About POU domain, class 3, transcription factor 3
POU domain, class 3, transcription factor 3 (POU3F3) is a protein
from Homo sapiens identified by UniProt accession
P20264, 500 residues long.
MolForge cross-references it against 0 known binders and
186 disease associations.
Target properties
| Protein name | POU domain, class 3, transcription factor 3 |
|---|
| UniProt accession | P20264 |
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| Gene | POU3F3 |
|---|
| Organism | Homo sapiens |
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| Length | 500 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (186)
Diseases linked to this target (Open Targets).
- Snijders Blok-Fisher syndrome · score 0.70
- Intellectual disability · score 0.59
- genetic disorder · score 0.51
- body mass index · score 0.43
- cortical surface area measurement · score 0.42
- body fat percentage · score 0.40
- cortical thickness · score 0.38
- Global developmental delay · score 0.37
- Autistic behavior · score 0.37
- Delayed speech and language development · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P20264-F1 | alphafold | PREDICTED | 56.19 | — |
Amino-acid sequence (500 residues)
MATAASNPYL PGNSLLAAGS IVHSDAAGAG GGGGGGGGGG GGGAGGGGGG MQPGSAAVTS GAYRGDPSSV KMVQSDFMQG AMAASNGGHM LSHAHQWVTA LPHAAAAAAA AAAAAVEASS PWSGSAVGMA GSPQQPPQPP PPPPQGPDVK GGAGRDDLHA GTALHHRGPP HLGPPPPPPH QGHPGGWGAA AAAAAAAAAA AAAAHLPSMA GGQQPPPQSL LYSQPGGFTV NGMLSAPPGP GGGGGGAGGG AQSLVHPGLV RGDTPELAEH HHHHHHHAHP HPPHPHHAQG PPHHGGGGGG AGPGLNSHDP HSDEDTPTSD DLEQFAKQFK QRRIKLGFTQ ADVGLALGTL YGNVFSQTTI CRFEALQLSF KNMCKLKPLL NKWLEEADSS TGSPTSIDKI AAQGRKRKKR TSIEVSVKGA LESHFLKCPK PSAQEITNLA DSLQLEKEVV RVWFCNRRQK EKRMTPPGIQ QQTPDDVYSQ VGTVSADTPP PHHGLQTSVQ
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