About POU domain, class 3, transcription factor 2
POU domain, class 3, transcription factor 2 (POU3F2) is a protein
from Homo sapiens identified by UniProt accession
P20265, 443 residues long.
MolForge cross-references it against 0 known binders and
111 disease associations.
Target properties
| Protein name | POU domain, class 3, transcription factor 2 |
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| UniProt accession | P20265 |
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| Gene | POU3F2 |
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| Organism | Homo sapiens |
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| Length | 443 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (111)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.55
- mathematical ability · score 0.46
- cognitive function measurement · score 0.43
- self reported educational attainment · score 0.42
- intelligence · score 0.25
- adolescent idiopathic scoliosis · score 0.25
- genetic disorder · score 0.19
- antisocial behaviour measurement · score 0.15
- attention deficit hyperactivity disorder · score 0.15
- substance abuse · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P20265-F1 | alphafold | PREDICTED | 60.90 | — |
Amino-acid sequence (443 residues)
MATAASNHYS LLTSSASIVH AEPPGGMQQG AGGYREAQSL VQGDYGALQS NGHPLSHAHQ WITALSHGGG GGGGGGGGGG GGGGGGGGDG SPWSTSPLGQ PDIKPSVVVQ QGGRGDELHG PGALQQQHQQ QQQQQQQQQQ QQQQQQQQQR PPHLVHHAAN HHPGPGAWRS AAAAAHLPPS MGASNGGLLY SQPSFTVNGM LGAGGQPAGL HHHGLRDAHD EPHHADHHPH PHSHPHQQPP PPPPPQGPPG HPGAHHDPHS DEDTPTSDDL EQFAKQFKQR RIKLGFTQAD VGLALGTLYG NVFSQTTICR FEALQLSFKN MCKLKPLLNK WLEEADSSSG SPTSIDKIAA QGRKRKKRTS IEVSVKGALE SHFLKCPKPS AQEITSLADS LQLEKEVVRV WFCNRRQKEK RMTPPGGTLP GAEDVYGGSR DTPPHHGVQT PVQ
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