Arachidonate 5-lipoxygenase-activating protein…

About Arachidonate 5-lipoxygenase-activating protein

Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) is a protein from Homo sapiens identified by UniProt accession P20292, 161 residues long. MolForge cross-references it against 0 known binders and 175 disease associations.

Target properties

Protein name	Arachidonate 5-lipoxygenase-activating protein
UniProt accession	P20292
Gene	ALOX5AP
Organism	Homo sapiens
Length	161 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (2)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (175)

Diseases linked to this target (Open Targets).

bipolar disorder · score 0.46
bipolar I disorder · score 0.33
acute coronary syndrome · score 0.26
risk-taking behaviour · score 0.26
cutaneous melanoma · score 0.13
asthma · score 0.11
inflammatory bowel disease · score 0.10
cystic fibrosis · score 0.09
acute myeloid leukemia · score 0.08
osteoarthritis · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P20292-F1	alphafold	PREDICTED	89.39	—

Amino-acid sequence (161 residues)

MDQETVGNVV LLAIVTLISV VQNGFFAHKV EHESRTQNGR SFQRTGTLAF ERVYTANQNC VDAYPTFLAV LWSAGLLCSQ VPAAFAGLMY LFVRQKYFVG YLGERTQSTP GYIFGKRIIL FLFLMSVAGI FNYYLIFFFG SDFENYIKTI STTISPLLLI P

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Arachidonate 5-lipoxygenase-activating protein (ALOX5AP)