About Protachykinin-1
Protachykinin-1 (TAC1) is a protein
from Homo sapiens identified by UniProt accession
P20366, 129 residues long.
MolForge cross-references it against 0 known binders and
817 disease associations.
Target properties
| Protein name | Protachykinin-1 |
|---|
| UniProt accession | P20366 |
|---|
| Gene | TAC1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 129 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (817)
Diseases linked to this target (Open Targets).
- risk-taking behaviour · score 0.36
- attention deficit hyperactivity disorder · score 0.28
- emotional symptom measurement · score 0.28
- feeling nervous measurement · score 0.28
- substance abuse · score 0.26
- antisocial behaviour measurement · score 0.26
- smoking status measurement · score 0.25
- social interaction measurement · score 0.25
- cutaneous melanoma · score 0.13
- breast milk measurement · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P20366-F1 | alphafold | PREDICTED | 66.88 | — |
Amino-acid sequence (129 residues)
MKILVALAVF FLVSTQLFAE EIGANDDLNY WSDWYDSDQI KEELPEPFEH LLQRIARRPK PQQFFGLMGK RDADSSIEKQ VALLKALYGH GQISHKRHKT DSFVGLMGKR ALNSVAYERS AMQNYERRR
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