About Nuclear receptor subfamily 1 group D member 1
Nuclear receptor subfamily 1 group D member 1 (NR1D1) is a protein
from Homo sapiens identified by UniProt accession
P20393, 614 residues long.
MolForge cross-references it against 0 known binders and
340 disease associations.
Target properties
| Protein name | Nuclear receptor subfamily 1 group D member 1 |
|---|
| UniProt accession | P20393 |
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| Gene | NR1D1 |
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| Organism | Homo sapiens |
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| Length | 614 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (340)
Diseases linked to this target (Open Targets).
- peripheral resistance to thyroid hormones · score 0.38
- reticulocyte count · score 0.28
- neurodegenerative disease · score 0.28
- sex hormone-binding globulin measurement · score 0.27
- multiple sclerosis · score 0.24
- neutrophil-to-lymphocyte ratio · score 0.23
- neutrophil count · score 0.23
- mean corpuscular volume · score 0.22
- total cholesterol measurement · score 0.21
- mitochondrial DNA measurement · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P20393-F1 | alphafold | PREDICTED | 62.89 | — |
Amino-acid sequence (614 residues)
MTTLDSNNNT GGVITYIGSS GSSPSRTSPE SLYSDNSNGS FQSLTQGCPT YFPPSPTGSL TQDPARSFGS IPPSLSDDGS PSSSSSSSSS SSSFYNGSPP GSLQVAMEDS SRVSPSKSTS NITKLNGMVL LCKVCGDVAS GFHYGVHACE GCKGFFRRSI QQNIQYKRCL KNENCSIVRI NRNRCQQCRF KKCLSVGMSR DAVRFGRIPK REKQRMLAEM QSAMNLANNQ LSSQCPLETS PTQHPTPGPM GPSPPPAPVP SPLVGFSQFP QQLTPPRSPS PEPTVEDVIS QVARAHREIF TYAHDKLGSS PGNFNANHAS GSPPATTPHR WENQGCPPAP NDNNTLAAQR HNEALNGLRQ APSSYPPTWP PGPAHHSCHQ SNSNGHRLCP THVYAAPEGK APANSPRQGN SKNVLLACPM NMYPHGRSGR TVQEIWEDFS MSFTPAVREV VEFAKHIPGF RDLSQHDQVT LLKAGTFEVL MVRFASLFNV KDQTVMFLSR TTYSLQELGA MGMGDLLSAM FDFSEKLNSL ALTEEELGLF TAVVLVSADR SGMENSASVE QLQETLLRAL RALVLKNRPL ETSRFTKLLL KLPDLRTLNN MHSEKLLSFR VDAQ
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