About Pro-thyrotropin-releasing hormone
Pro-thyrotropin-releasing hormone (TRH) is a protein
from Homo sapiens identified by UniProt accession
P20396, 242 residues long.
MolForge cross-references it against 0 known binders and
587 disease associations.
Target properties
| Protein name | Pro-thyrotropin-releasing hormone |
|---|
| UniProt accession | P20396 |
|---|
| Gene | TRH |
|---|
| Organism | Homo sapiens |
|---|
| Length | 242 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (587)
Diseases linked to this target (Open Targets).
- sex hormone-binding globulin measurement · score 0.29
- PHF-tau measurement · score 0.27
- glioblastoma multiforme · score 0.26
- ovarian cancer · score 0.26
- head and neck squamous cell carcinoma · score 0.16
- body height · score 0.14
- isolated thyrotropin-releasing hormone deficiency · score 0.12
- Seizure · score 0.12
- Global developmental delay · score 0.12
- chorea · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P20396-F1 | alphafold | PREDICTED | 59.68 | — |
Amino-acid sequence (242 residues)
MPGPWLLLAL ALTLNLTGVP GGRAQPEAAQ QEAVTAAEHP GLDDFLRQVE RLLFLRENIQ RLQGDQGEHS ASQIFQSDWL SKRQHPGKRE EEEEEGVEEE EEEEGGAVGP HKRQHPGRRE DEASWSVDVT QHKRQHPGRR SPWLAYAVPK RQHPGRRLAD PKAQRSWEEE EEEEEREEDL MPEKRQHPGK RALGGPCGPQ GAYGQAGLLL GLLDDLSRSQ GAEEKRQHPG RRAAWVREPL EE
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