About Interferon-induced GTP-binding protein Mx1
Interferon-induced GTP-binding protein Mx1 (MX1) is a protein
from Homo sapiens identified by UniProt accession
P20591, 662 residues long.
MolForge cross-references it against 0 known binders and
435 disease associations.
Target properties
| Protein name | Interferon-induced GTP-binding protein Mx1 |
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| UniProt accession | P20591 |
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| Gene | MX1 |
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| Organism | Homo sapiens |
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| Length | 662 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (435)
Diseases linked to this target (Open Targets).
- cancer · score 0.34
- diabetes mellitus · score 0.34
- atrial fibrillation · score 0.33
- coronary artery disease · score 0.33
- stroke · score 0.33
- heart failure · score 0.33
- mortality · score 0.33
- PHF-tau measurement · score 0.30
- IGF-1 measurement · score 0.29
- arterial stiffness measurement · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P20591-F1 | alphafold | PREDICTED | 83.19 | — |
Amino-acid sequence (662 residues)
MVVSEVDIAK ADPAAASHPL LLNGDATVAQ KNPGSVAENN LCSQYEEKVR PCIDLIDSLR ALGVEQDLAL PAIAVIGDQS SGKSSVLEAL SGVALPRGSG IVTRCPLVLK LKKLVNEDKW RGKVSYQDYE IEISDASEVE KEINKAQNAI AGEGMGISHE LITLEISSRD VPDLTLIDLP GITRVAVGNQ PADIGYKIKT LIKKYIQRQE TISLVVVPSN VDIATTEALS MAQEVDPEGD RTIGILTKPD LVDKGTEDKV VDVVRNLVFH LKKGYMIVKC RGQQEIQDQL SLSEALQREK IFFENHPYFR DLLEEGKATV PCLAEKLTSE LITHICKSLP LLENQIKETH QRITEELQKY GVDIPEDENE KMFFLIDKVN AFNQDITALM QGEETVGEED IRLFTRLRHE FHKWSTIIEN NFQEGHKILS RKIQKFENQY RGRELPGFVN YRTFETIVKQ QIKALEEPAV DMLHTVTDMV RLAFTDVSIK NFEEFFNLHR TAKSKIEDIR AEQEREGEKL IRLHFQMEQI VYCQDQVYRG ALQKVREKEL EEEKKKKSWD FGAFQSSSAT DSSMEEIFQH LMAYHQEASK RISSHIPLII QFFMLQTYGQ QLQKAMLQLL QDKDTYSWLL KERSDTSDKR KFLKERLARL TQARRRLAQF PG
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