About Interferon-induced GTP-binding protein Mx2
Interferon-induced GTP-binding protein Mx2 (MX2) is a protein
from Homo sapiens identified by UniProt accession
P20592, 715 residues long.
MolForge cross-references it against 0 known binders and
163 disease associations.
Target properties
| Protein name | Interferon-induced GTP-binding protein Mx2 |
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| UniProt accession | P20592 |
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| Gene | MX2 |
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| Organism | Homo sapiens |
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| Length | 715 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (163)
Diseases linked to this target (Open Targets).
- melanoma · score 0.43
- cutaneous melanoma · score 0.42
- nevus count · score 0.38
- mean reticulocyte volume · score 0.25
- thyroid gland adenocarcinoma · score 0.18
- blood protein measurement · score 0.15
- HIV-1 infection · score 0.09
- p-cresol sulfate measurement · score 0.08
- infection · score 0.08
- infect · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P20592-F1 | alphafold | PREDICTED | 78.17 | — |
Amino-acid sequence (715 residues)
MSKAHKPWPY RRRSQFSSRK YLKKEMNSFQ QQPPPFGTVP PQMMFPPNWQ GAEKDAAFLA KDFNFLTLNN QPPPGNRSQP RAMGPENNLY SQYEQKVRPC IDLIDSLRAL GVEQDLALPA IAVIGDQSSG KSSVLEALSG VALPRGSGIV TRCPLVLKLK KQPCEAWAGR ISYRNTELEL QDPGQVEKEI HKAQNVMAGN GRGISHELIS LEITSPEVPD LTIIDLPGIT RVAVDNQPRD IGLQIKALIK KYIQRQQTIN LVVVPCNVDI ATTEALSMAH EVDPEGDRTI GILTKPDLMD RGTEKSVMNV VRNLTYPLKK GYMIVKCRGQ QEITNRLSLA EATKKEITFF QTHPYFRVLL EEGSATVPRL AERLTTELIM HIQKSLPLLE GQIRESHQKA TEELRRCGAD IPSQEADKMF FLIEKIKMFN QDIEKLVEGE EVVRENETRL YNKIREDFKN WVGILATNTQ KVKNIIHEEV EKYEKQYRGK ELLGFVNYKT FEIIVHQYIQ QLVEPALSML QKAMEIIQQA FINVAKKHFG EFFNLNQTVQ STIEDIKVKH TAKAENMIQL QFRMEQMVFC QDQIYSVVLK KVREEIFNPL GTPSQNMKLN SHFPSNESSV SSFTEIGIHL NAYFLETSKR LANQIPFIIQ YFMLRENGDS LQKAMMQILQ EKNRYSWLLQ EQSETATKRR ILKERIYRLT QARHALCQFS SKEIH
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