About Proteasome subunit beta type-1
Proteasome subunit beta type-1 (PSMB1) is a protein
from Homo sapiens identified by UniProt accession
P20618, 241 residues long.
MolForge cross-references it against 0 known binders and
78 disease associations.
Target properties
| Protein name | Proteasome subunit beta type-1 |
|---|
| UniProt accession | P20618 |
|---|
| Gene | PSMB1 |
|---|
| Organism | Homo sapiens |
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| Length | 241 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (4)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (78)
Diseases linked to this target (Open Targets).
- HIV infection · score 0.46
- ovarian cancer · score 0.29
- blood protein measurement · score 0.29
- endometrial cancer · score 0.29
- urinary bladder cancer · score 0.28
- glioblastoma multiforme · score 0.28
- gastric adenocarcinoma · score 0.27
- multiple myeloma · score 0.10
- ependymoma · score 0.07
- Paraganglioma · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P20618-F1 | alphafold | PREDICTED | 91.38 | — |
Amino-acid sequence (241 residues)
MLSSTAMYSA PGRDLGMEPH RAAGPLQLRF SPYVFNGGTI LAIAGEDFAI VASDTRLSEG FSIHTRDSPK CYKLTDKTVI GCSGFHGDCL TLTKIIEARL KMYKHSNNKA MTTGAIAAML STILYSRRFF PYYVYNIIGG LDEEGKGAVY SFDPVGSYQR DSFKAGGSAS AMLQPLLDNQ VGFKNMQNVE HVPLSLDRAM RLVKDVFISA AERDVYTGDA LRICIVTKEG IREETVSLRK D
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