Cation-dependent mannose-6-phosphate receptor (M6PR)

About Cation-dependent mannose-6-phosphate receptor

Cation-dependent mannose-6-phosphate receptor (M6PR) is a protein from Homo sapiens identified by UniProt accession P20645, 277 residues long. MolForge cross-references it against 0 known binders and 53 disease associations.

Target properties

Protein name	Cation-dependent mannose-6-phosphate receptor
UniProt accession	P20645
Gene	M6PR
Organism	Homo sapiens
Length	277 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (53)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.37
total cholesterol measurement · score 0.33
blood protein measurement · score 0.30
body height · score 0.29
high density lipoprotein cholesterol measurement · score 0.28
type 1 diabetes mellitus · score 0.26
low density lipoprotein cholesterol measurement · score 0.25
apolipoprotein A 1 measurement · score 0.23
monocyte count · score 0.23
alkaline phosphatase measurement · score 0.23

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P20645-F1	alphafold	PREDICTED	84.79	—

Amino-acid sequence (277 residues)

MFPFYSCWRT GLLLLLLAVA VRESWQTEEK TCDLVGEKGK ESEKELALVK RLKPLFNKSF ESTVGQGSDT YIYIFRVCRE AGNHTSGAGL VQINKSNGKE TVVGRLNETH IFNGSNWIML IYKGGDEYDN HCGKEQRRAV VMISCNRHTL ADNFNPVSEE RGKVQDCFYL FEMDSSLACS PEISHLSVGS ILLVTFASLV AVYVVGGFLY QRLVVGAKGM EQFPHLAFWQ DLGNLVADGC DFVCRSKPRN VPAAYRGVGD DQLGEESEER DDHLLPM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards