About Cytochrome c oxidase subunit 5A, mitochondrial
Cytochrome c oxidase subunit 5A, mitochondrial (COX5A) is a protein
from Homo sapiens identified by UniProt accession
P20674, 150 residues long.
MolForge cross-references it against 0 known binders and
140 disease associations.
Target properties
| Protein name | Cytochrome c oxidase subunit 5A, mitochondrial |
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| UniProt accession | P20674 |
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| Gene | COX5A |
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| Organism | Homo sapiens |
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| Length | 150 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (140)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- mitochondrial complex 4 deficiency, nuclear type 20 · score 0.51
- mitochondrial complex IV deficiency, nuclear type 23 · score 0.49
- neuroinflammatory disorder · score 0.45
- Isolated cytochrome C oxidase deficiency · score 0.37
- breast adenocarcinoma · score 0.23
- smoking status measurement · score 0.19
- endometrial cancer · score 0.18
- diastolic blood pressure · score 0.18
- systolic blood pressure · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P20674-F1 | alphafold | PREDICTED | 87.24 | — |
Amino-acid sequence (150 residues)
MLGAALRRCA VAATTRADPR GLLHSARTPG PAVAIQSVRC YSHGSQETDE EFDARWVTYF NKPDIDAWEL RKGINTLVTY DMVPEPKIID AALRACRRLN DFASTVRILE VVKDKAGPHK EIYPYVIQEL RPTLNELGIS TPEELGLDKV
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