About Lamin-B1
Lamin-B1 (LMNB1) is a protein
from Homo sapiens identified by UniProt accession
P20700, 586 residues long.
MolForge cross-references it against 0 known binders and
287 disease associations.
Target properties
| Protein name | Lamin-B1 |
|---|
| UniProt accession | P20700 |
|---|
| Gene | LMNB1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 586 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (287)
Diseases linked to this target (Open Targets).
- adult-onset autosomal dominant demyelinating leukodystrophy · score 0.67
- Autosomal dominant microcephaly · score 0.64
- Adult-onset autosomal dominant leukodystrophy · score 0.52
- Syndrome with microcephaly as major feature · score 0.49
- basophil count · score 0.48
- genetic disorder · score 0.47
- basophil percentage of leukocytes · score 0.39
- neurodegenerative disease · score 0.37
- Alzheimer disease · score 0.37
- autosomal dominant primary microcephaly · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P20700-F1 | alphafold | PREDICTED | 82.41 | — |
Amino-acid sequence (586 residues)
MATATPVPPR MGSRAGGPTT PLSPTRLSRL QEKEELRELN DRLAVYIDKV RSLETENSAL QLQVTEREEV RGRELTGLKA LYETELADAR RALDDTARER AKLQIELGKC KAEHDQLLLN YAKKESDLNG AQIKLREYEA ALNSKDAALA TALGDKKSLE GDLEDLKDQI AQLEASLAAA KKQLADETLL KVDLENRCQS LTEDLEFRKS MYEEEINETR RKHETRLVEV DSGRQIEYEY KLAQALHEMR EQHDAQVRLY KEELEQTYHA KLENARLSSE MNTSTVNSAR EELMESRMRI ESLSSQLSNL QKESRACLER IQELEDLLAK EKDNSRRMLT DKEREMAEIR DQMQQQLNDY EQLLDVKLAL DMEISAYRKL LEGEEERLKL SPSPSSRVTV SRASSSRSVR TTRGKRKRVD VEESEASSSV SISHSASATG NVCIEEIDVD GKFIRLKNTS EQDQPMGGWE MIRKIGDTSV SYKYTSRYVL KAGQTVTIWA ANAGVTASPP TDLIWKNQNS WGTGEDVKVI LKNSQGEEVA QRSTVFKTTI PEEEEEEEEA AGVVVEEELF HQQGTPRASN RSCAIM
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