About Aromatic-L-amino-acid decarboxylase
Aromatic-L-amino-acid decarboxylase (DDC) is a protein
from Homo sapiens identified by UniProt accession
P20711, 480 residues long.
MolForge cross-references it against 0 known binders and
412 disease associations.
Target properties
| Protein name | Aromatic-L-amino-acid decarboxylase |
|---|
| UniProt accession | P20711 |
|---|
| Gene | DDC |
|---|
| Organism | Homo sapiens |
|---|
| Length | 480 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (412)
Diseases linked to this target (Open Targets).
- aromatic L-amino acid decarboxylase deficiency · score 0.83
- Parkinson disease · score 0.62
- depressive disorder · score 0.56
- injury · score 0.55
- stroke · score 0.51
- Back pain · score 0.47
- postencephalitic Parkinson disease · score 0.47
- genetic disorder · score 0.47
- alcohol drinking · score 0.46
- secondary Parkinson disease · score 0.46
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P20711-F1 | alphafold | PREDICTED | 96.83 | — |
Amino-acid sequence (480 residues)
MNASEFRRRG KEMVDYMANY MEGIEGRQVY PDVEPGYLRP LIPAAAPQEP DTFEDIINDV EKIIMPGVTH WHSPYFFAYF PTASSYPAML ADMLCGAIGC IGFSWAASPA CTELETVMMD WLGKMLELPK AFLNEKAGEG GGVIQGSASE ATLVALLAAR TKVIHRLQAA SPELTQAAIM EKLVAYSSDQ AHSSVERAGL IGGVKLKAIP SDGNFAMRAS ALQEALERDK AAGLIPFFMV ATLGTTTCCS FDNLLEVGPI CNKEDIWLHV DAAYAGSAFI CPEFRHLLNG VEFADSFNFN PHKWLLVNFD CSAMWVKKRT DLTGAFRLDP TYLKHSHQDS GLITDYRHWQ IPLGRRFRSL KMWFVFRMYG VKGLQAYIRK HVQLSHEFES LVRQDPRFEI CVEVILGLVC FRLKGSNKVN EALLQRINSA KKIHLVPCHL RDKFVLRFAI CSRTVESAHV QRAWEHIKEL AADVLRAERE
Explore Aromatic-L-amino-acid decarboxylase with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets