About Granzyme H
Granzyme H (GZMH) is a protein
from Homo sapiens identified by UniProt accession
P20718, 246 residues long.
MolForge cross-references it against 0 known binders and
98 disease associations.
Target properties
| Protein name | Granzyme H |
|---|
| UniProt accession | P20718 |
|---|
| Gene | GZMH |
|---|
| Organism | Homo sapiens |
|---|
| Length | 246 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (98)
Diseases linked to this target (Open Targets).
- endometrial cancer · score 0.18
- lung adenocarcinoma · score 0.12
- interleukin 10 measurement · score 0.05
- mastiha supplement exposure measurement · score 0.05
- neoplasm · score 0.05
- Acute hepatic failure · score 0.03
- hepatocellular carcinoma · score 0.03
- cancer · score 0.02
- microphthalmia with limb anomalies · score 0.01
- clear cell renal carcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P20718-F1 | alphafold | PREDICTED | 92.43 | — |
Amino-acid sequence (246 residues)
MQPFLLLLAF LLTPGAGTEE IIGGHEAKPH SRPYMAFVQF LQEKSRKRCG GILVRKDFVL TAAHCQGSSI NVTLGAHNIK EQERTQQFIP VKRPIPHPAY NPKNFSNDIM LLQLERKAKW TTAVRPLRLP SSKAQVKPGQ LCSVAGWGYV SMSTLATTLQ EVLLTVQKDC QCERLFHGNY SRATEICVGD PKKTQTGFKG DSGGPLVCKD VAQGILSYGN KKGTPPGVYI KVSHFLPWIK RTMKRL
Explore Granzyme H with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets