B-cell lymphoma 3 protein (BCL3)

About B-cell lymphoma 3 protein

B-cell lymphoma 3 protein (BCL3) is a protein from Homo sapiens identified by UniProt accession P20749, 454 residues long. MolForge cross-references it against 0 known binders and 520 disease associations.

Target properties

Protein name	B-cell lymphoma 3 protein
UniProt accession	P20749
Gene	BCL3
Organism	Homo sapiens
Length	454 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (520)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.45
colon adenocarcinoma · score 0.37
bile duct carcinoma · score 0.37
colorectal adenocarcinoma · score 0.37
eosinophil count · score 0.33
high density lipoprotein cholesterol measurement · score 0.31
low density lipoprotein cholesterol measurement · score 0.31
skin basal cell carcinoma · score 0.30
hepatocellular carcinoma · score 0.29
melanoma · score 0.29

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P20749-F1	alphafold	PREDICTED	71.34	—

Amino-acid sequence (454 residues)

MPRCPAGAMD EGPVDLRTRP KAAGLPGAAL PLRKRPLRAP SPEPAAPRGA AGLVVPLDPL RGGCDLPAVP GPPHGLARPE ALYYPGALLP LYPTRAMGSP FPLVNLPTPL YPMMCPMEHP LSADIAMATR ADEDGDTPLH IAVVQGNLPA VHRLVNLFQQ GGRELDIYNN LRQTPLHLAV ITTLPSVVRL LVTAGASPMA LDRHGQTAAH LACEHRSPTC LRALLDSAAP GTLDLEARNY DGLTALHVAV NTECQETVQL LLERGADIDA VDIKSGRSPL IHAVENNSLS MVQLLLQHGA NVNAQMYSGS SALHSASGRG LLPLVRTLVR SGADSSLKNC HNDTPLMVAR SRRVIDILRG KATRPASTSQ PDPSPDRSAN TSPESSSRLS SNGLLSASPS SSPSQSPPRD PPGFPMAPPN FFLPSPSPPA FLPFAGVLRG PGRPVPPSPA PGGS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards