About Neurotrophin-3
Neurotrophin-3 (NTF3) is a protein
from Homo sapiens identified by UniProt accession
P20783, 257 residues long.
MolForge cross-references it against 0 known binders and
397 disease associations.
Target properties
| Protein name | Neurotrophin-3 |
|---|
| UniProt accession | P20783 |
|---|
| Gene | NTF3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 257 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (397)
Diseases linked to this target (Open Targets).
- cancer · score 0.37
- insomnia · score 0.31
- BMI-adjusted waist circumference · score 0.28
- body height · score 0.26
- diastolic blood pressure · score 0.25
- drug use measurement · score 0.22
- neuroimaging measurement · score 0.13
- cortical surface area measurement · score 0.12
- Hirschsprung disease · score 0.12
- brain measurement · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P20783-F1 | alphafold | PREDICTED | 73.76 | — |
Amino-acid sequence (257 residues)
MSILFYVIFL AYLRGIQGNN MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK QMVDVKENYQ STLPKAEAPR EPERGGPAKS AFQPVIAMDT ELLRQQRRYN SPRVLLSDST PLEPPPLYLM EDYVGSPVVA NRTSRRKRYA EHKSHRGEYS VCDSESLWVT DKSSAIDIRG HQVTVLGEIK TGNSPVKQYF YETRCKEARP VKNGCRGIDD KHWNSQCKTS QTYVRALTSE NNKLVGWRWI RIDTSCVCAL SRKIGRT
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