About Serine/threonine-protein kinase MAK
Serine/threonine-protein kinase MAK (MAK) is a protein
from Homo sapiens identified by UniProt accession
P20794, 623 residues long.
MolForge cross-references it against 0 known binders and
62 disease associations.
Target properties
| Protein name | Serine/threonine-protein kinase MAK |
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| UniProt accession | P20794 |
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| Gene | MAK |
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| Organism | Homo sapiens |
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| Length | 623 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (62)
Diseases linked to this target (Open Targets).
- retinitis pigmentosa · score 0.72
- Retinal dystrophy · score 0.51
- Posterior column ataxia - retinitis pigmentosa · score 0.42
- inherited retinal dystrophy · score 0.37
- lysosomal storage disease · score 0.35
- Alzheimer disease · score 0.35
- neurodegenerative disease · score 0.35
- Parkinson disease · score 0.35
- multiple sclerosis · score 0.35
- isolated macular dystrophy · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P20794-F1 | alphafold | PREDICTED | 62.14 | — |
Amino-acid sequence (623 residues)
MNRYTTMRQL GDGTYGSVLM GKSNESGELV AIKRMKRKFY SWDECMNLRE VKSLKKLNHA NVIKLKEVIR ENDHLYFIFE YMKENLYQLM KDRNKLFPES VIRNIMYQIL QGLAFIHKHG FFHRDMKPEN LLCMGPELVK IADFGLAREL RSQPPYTDYV STRWYRAPEV LLRSSVYSSP IDVWAVGSIM AELYMLRPLF PGTSEVDEIF KICQVLGTPK KSDWPEGYQL ASSMNFRFPQ CVPINLKTLI PNASNEAIQL MTEMLNWDPK KRPTASQALK HPYFQVGQVL GPSSNHLESK QSLNKQLQPL ESKPSLVEVE PKPLPDIIDQ VVGQPQPKTS QQPLQPIQPP QNLSVQQPPK QQSQEKPPQT LFPSIVKNMP TKPNGTLSHK SGRRRWGQTI FKSGDSWEEL EDYDFGASHS KKPSMGVFKE KRKKDSPFRL PEPVPSGSNH STGENKSLPA VTSLKSDSEL STAPTSKQYY LKQSRYLPGV NPKKVSLIAS GKEINPHTWS NQLFPKSLGP VGAELAFKRS NAGNLGSYAT YNQSGYIPSF LKKEVQSAGQ RIHLAPLNAT ASEYTWNTKT GRGQFSGRTY NPTAKNLNIV NRAQPIPSVH GRTDWVAKYG GHR
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