Endothelin-2 (EDN2)

About Endothelin-2

Endothelin-2 (EDN2) is a protein from Homo sapiens identified by UniProt accession P20800, 178 residues long. MolForge cross-references it against 0 known binders and 160 disease associations.

Target properties

Protein name	Endothelin-2
UniProt accession	P20800
Gene	EDN2
Organism	Homo sapiens
Length	178 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (160)

Diseases linked to this target (Open Targets).

PR interval · score 0.35
aortic measurement · score 0.33
neurodegenerative disease · score 0.26
breast adenocarcinoma · score 0.25
balding measurement · score 0.24
hair colour measurement · score 0.24
heel bone mineral density · score 0.20
testosterone measurement · score 0.14
PHF-tau measurement · score 0.14
low grade glioma · score 0.14

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P20800-F1	alphafold	PREDICTED	64.44	—

Amino-acid sequence (178 residues)

MVSVPTTWCS VALALLVALH EGKGQAAATL EQPASSSHAQ GTHLRLRRCS CSSWLDKECV YFCHLDIIWV NTPEQTAPYG LGNPPRRRRR SLPRRCQCSS ARDPACATFC LRRPWTEAGA VPSRKSPADV FQTGKTGATT GELLQRLRDI STVKSLFAKR QQEAMREPRS THSRWRKR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards