About Calpain-3
Calpain-3 (CAPN3) is a protein
from Homo sapiens identified by UniProt accession
P20807, 821 residues long.
MolForge cross-references it against 0 known binders and
348 disease associations.
Target properties
| Protein name | Calpain-3 |
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| UniProt accession | P20807 |
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| Gene | CAPN3 |
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| Organism | Homo sapiens |
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| Length | 821 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (348)
Diseases linked to this target (Open Targets).
- autosomal recessive limb-girdle muscular dystrophy type 2A · score 0.84
- muscular dystrophy, limb-girdle, autosomal dominant 4 · score 0.73
- autosomal recessive limb-girdle muscular dystrophy · score 0.64
- Abnormality of the musculature · score 0.55
- muscular dystrophy · score 0.49
- Muscle weakness · score 0.48
- limb-girdle muscular dystrophy · score 0.47
- Shoulder girdle muscle weakness · score 0.46
- myopathy · score 0.43
- Lower-limb joint contracture · score 0.43
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P20807-F1 | alphafold | PREDICTED | 78.24 | — |
Amino-acid sequence (821 residues)
MPTVISASVA PRTAAEPRSP GPVPHPAQSK ATEAGGGNPS GIYSAIISRN FPIIGVKEKT FEQLHKKCLE KKVLYVDPEF PPDETSLFYS QKFPIQFVWK RPPEICENPR FIIDGANRTD ICQGELGDCW FLAAIACLTL NQHLLFRVIP HDQSFIENYA GIFHFQFWRY GEWVDVVIDD CLPTYNNQLV FTKSNHRNEF WSALLEKAYA KLHGSYEALK GGNTTEAMED FTGGVAEFFE IRDAPSDMYK IMKKAIERGS LMGCSIDDGT NMTYGTSPSG LNMGELIARM VRNMDNSLLQ DSDLDPRGSD ERPTRTIIPV QYETRMACGL VRGHAYSVTG LDEVPFKGEK VKLVRLRNPW GQVEWNGSWS DRWKDWSFVD KDEKARLQHQ VTEDGEFWMS YEDFIYHFTK LEICNLTADA LQSDKLQTWT VSVNEGRWVR GCSAGGCRNF PDTFWTNPQY RLKLLEEDDD PDDSEVICSF LVALMQKNRR KDRKLGASLF TIGFAIYEVP KEMHGNKQHL QKDFFLYNAS KARSKTYINM REVSQRFRLP PSEYVIVPST YEPHQEGEFI LRVFSEKRNL SEEVENTISV DRPVKKKKTK PIIFVSDRAN SNKELGVDQE SEEGKGKTSP DKQKQSPQPQ PGSSDQESEE QQQFRNIFKQ IAGDDMEICA DELKKVLNTV VNKHKDLKTH GFTLESCRSM IALMDTDGSG KLNLQEFHHL WNKIKAWQKI FKHYDTDQSG TINSYEMRNA VNDAGFHLNN QLYDIITMRY ADKHMNIDFD SFICCFVRLE GMFRAFHAFD KDGDGIIKLN VLEWLQLTMY A
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