Interleukin-11 (IL11)

About Interleukin-11

Interleukin-11 (IL11) is a protein from Homo sapiens identified by UniProt accession P20809, 199 residues long. MolForge cross-references it against 0 known binders and 491 disease associations.

Target properties

Protein name	Interleukin-11
UniProt accession	P20809
Gene	IL11
Organism	Homo sapiens
Length	199 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (491)

Diseases linked to this target (Open Targets).

lean body mass · score 0.36
osteoarthritis · score 0.35
appendicular lean mass · score 0.35
body height · score 0.35
osteoarthritis, hip · score 0.34
fat body mass · score 0.32
vital capacity · score 0.31
smoking status measurement · score 0.29
sitting height measurement · score 0.28
whole body water mass · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P20809-F1	alphafold	PREDICTED	82.66	—

Amino-acid sequence (199 residues)

MNCVCRLVLV VLSLWPDTAV APGPPPGPPR VSPDPRAELD STVLLTRSLL ADTRQLAAQL RDKFPADGDH NLDSLPTLAM SAGALGALQL PGVLTRLRAD LLSYLRHVQW LRRAGGSSLK TLEPELGTLQ ARLDRLLRRL QLLMSRLALP QPPPDPPAPP LAPPSSAWGG IRAAHAILGG LHLTLDWAVR GLLLLKTRL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards