About Cytochrome P450 2B6
Cytochrome P450 2B6 (CYP2B6) is a protein
from Homo sapiens identified by UniProt accession
P20813, 491 residues long.
MolForge cross-references it against 0 known binders and
369 disease associations.
Target properties
| Protein name | Cytochrome P450 2B6 |
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| UniProt accession | P20813 |
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| Gene | CYP2B6 |
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| Organism | Homo sapiens |
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| Length | 491 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (5)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (369)
Diseases linked to this target (Open Targets).
- virologic response measurement · score 0.51
- DDT metabolite measurement · score 0.38
- trait in response to efavirenz · score 0.36
- gestational serum measurement · score 0.31
- polychlorinated biphenyls measurement · score 0.30
- polybrominated biphenyl measurement · score 0.25
- polybrominated diphenyl ether measurement · score 0.25
- organochlorine pesticide measurement · score 0.24
- cutaneous melanoma · score 0.23
- glioblastoma multiforme · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P20813-F1 | alphafold | PREDICTED | 94.16 | — |
Amino-acid sequence (491 residues)
MELSVLLFLA LLTGLLLLLV QRHPNTHDRL PPGPRPLPLL GNLLQMDRRG LLKSFLRFRE KYGDVFTVHL GPRPVVMLCG VEAIREALVD KAEAFSGRGK IAMVDPFFRG YGVIFANGNR WKVLRRFSVT TMRDFGMGKR SVEERIQEEA QCLIEELRKS KGALMDPTFL FQSITANIIC SIVFGKRFHY QDQEFLKMLN LFYQTFSLIS SVFGQLFELF SGFLKYFPGA HRQVYKNLQE INAYIGHSVE KHRETLDPSA PKDLIDTYLL HMEKEKSNAH SEFSHQNLNL NTLSLFFAGT ETTSTTLRYG FLLMLKYPHV AERVYREIEQ VIGPHRPPEL HDRAKMPYTE AVIYEIQRFS DLLPMGVPHI VTQHTSFRGY IIPKDTEVFL ILSTALHDPH YFEKPDAFNP DHFLDANGAL KKTEAFIPFS LGKRICLGEG IARAELFLFF TTILQNFSMA SPVAPEDIDL TPQECGVGKI PPTYQIRFLP R
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