About Hepatocyte nuclear factor 1-alpha
Hepatocyte nuclear factor 1-alpha (HNF1A) is a protein
from Homo sapiens identified by UniProt accession
P20823, 631 residues long.
MolForge cross-references it against 0 known binders and
775 disease associations.
Target properties
| Protein name | Hepatocyte nuclear factor 1-alpha |
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| UniProt accession | P20823 |
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| Gene | HNF1A |
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| Organism | Homo sapiens |
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| Length | 631 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (775)
Diseases linked to this target (Open Targets).
- maturity-onset diabetes of the young type 3 · score 0.75
- type 2 diabetes mellitus · score 0.74
- MODY · score 0.72
- monogenic diabetes · score 0.68
- type 1 diabetes mellitus · score 0.67
- hepatocellular adenoma · score 0.66
- diabetes mellitus · score 0.66
- maturity-onset diabetes of the young · score 0.61
- nonpapillary renal cell carcinoma · score 0.53
- hepatocellular carcinoma · score 0.52
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P20823-F1 | alphafold | PREDICTED | 56.95 | — |
Amino-acid sequence (631 residues)
MVSKLSQLQT ELLAALLESG LSKEALIQAL GEPGPYLLAG EGPLDKGESC GGGRGELAEL PNGLGETRGS EDETDDDGED FTPPILKELE NLSPEEAAHQ KAVVETLLQE DPWRVAKMVK SYLQQHNIPQ REVVDTTGLN QSHLSQHLNK GTPMKTQKRA ALYTWYVRKQ REVAQQFTHA GQGGLIEEPT GDELPTKKGR RNRFKWGPAS QQILFQAYER QKNPSKEERE TLVEECNRAE CIQRGVSPSQ AQGLGSNLVT EVRVYNWFAN RRKEEAFRHK LAMDTYSGPP PGPGPGPALP AHSSPGLPPP ALSPSKVHGV RYGQPATSET AEVPSSSGGP LVTVSTPLHQ VSPTGLEPSH SLLSTEAKLV SAAGGPLPPV STLTALHSLE QTSPGLNQQP QNLIMASLPG VMTIGPGEPA SLGPTFTNTG ASTLVIGLAS TQAQSVPVIN SMGSSLTTLQ PVQFSQPLHP SYQQPLMPPV QSHVTQSPFM ATMAQLQSPH ALYSHKPEVA QYTHTGLLPQ TMLITDTTNL SALASLTPTK QVFTSDTEAS SESGLHTPAS QATTLHVPSQ DPASIQHLQP AHRLSASPTV SSSSLVLYQS SDSSNGQSHL LPSNHSVIET FISTQMASSS Q
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