About Ephrin-A1
Ephrin-A1 (EFNA1) is a protein
from Homo sapiens identified by UniProt accession
P20827, 205 residues long.
MolForge cross-references it against 0 known binders and
275 disease associations.
Target properties
| Protein name | Ephrin-A1 |
|---|
| UniProt accession | P20827 |
|---|
| Gene | EFNA1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 205 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (275)
Diseases linked to this target (Open Targets).
- electrocardiography · score 0.30
- serum gamma-glutamyl transferase measurement · score 0.25
- digit length ratio · score 0.25
- low density lipoprotein cholesterol measurement · score 0.24
- serum alanine aminotransferase measurement · score 0.22
- cataract · score 0.22
- aspartate aminotransferase measurement · score 0.20
- hair colour measurement · score 0.19
- lung adenocarcinoma · score 0.18
- ulcerative colitis · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P20827-F1 | alphafold | PREDICTED | 79.08 | — |
Amino-acid sequence (205 residues)
MEFLWAPLLG LCCSLAAADR HTVFWNSSNP KFRNEDYTIH VQLNDYVDII CPHYEDHSVA DAAMEQYILY LVEHEEYQLC QPQSKDQVRW QCNRPSAKHG PEKLSEKFQR FTPFTLGKEF KEGHSYYYIS KPIHQHEDRC LRLKVTVSGK ITHSPQAHDN PQEKRLAADD PEVRVLHSIG HSAAPRLFPL AWTVLLLPLL LLQTP
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