About Inosine-5'-monophosphate dehydrogenase 1
Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) is a protein
from Homo sapiens identified by UniProt accession
P20839, 514 residues long.
MolForge cross-references it against 0 known binders and
309 disease associations.
Target properties
| Protein name | Inosine-5'-monophosphate dehydrogenase 1 |
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| UniProt accession | P20839 |
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| Gene | IMPDH1 |
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| Organism | Homo sapiens |
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| Length | 514 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (4)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (309)
Diseases linked to this target (Open Targets).
- retinitis pigmentosa · score 0.72
- Leber congenital amaurosis · score 0.62
- chronic hepatitis C virus infection · score 0.61
- hepatitis C virus infection · score 0.60
- cirrhosis of liver · score 0.59
- acute graft vs. host disease · score 0.58
- lupus nephritis · score 0.58
- chronic kidney disease · score 0.58
- cytomegalovirus infection · score 0.56
- hepatocellular carcinoma · score 0.55
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P20839-F1 | alphafold | PREDICTED | 92.70 | — |
Amino-acid sequence (514 residues)
MADYLISGGT GYVPEDGLTA QQLFASADGL TYNDFLILPG FIDFIADEVD LTSALTRKIT LKTPLISSPM DTVTEADMAI AMALMGGIGF IHHNCTPEFQ ANEVRKVKKF EQGFITDPVV LSPSHTVGDV LEAKMRHGFS GIPITETGTM GSKLVGIVTS RDIDFLAEKD HTTLLSEVMT PRIELVVAPA GVTLKEANEI LQRSKKGKLP IVNDCDELVA IIARTDLKKN RDYPLASKDS QKQLLCGAAV GTREDDKYRL DLLTQAGVDV IVLDSSQGNS VYQIAMVHYI KQKYPHLQVI GGNVVTAAQA KNLIDAGVDG LRVGMGCGSI CITQEVMACG RPQGTAVYKV AEYARRFGVP IIADGGIQTV GHVVKALALG ASTVMMGSLL AATTEAPGEY FFSDGVRLKK YRGMGSLDAM EKSSSSQKRY FSEGDKVKIA QGVSGSIQDK GSIQKFVPYL IAGIQHGCQD IGARSLSVLR SMMYSGELKF EKRTMSAQIE GGVHGLHSYE KRLY
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