About C4b-binding protein beta chain
C4b-binding protein beta chain (C4BPB) is a protein
from Homo sapiens identified by UniProt accession
P20851, 252 residues long.
MolForge cross-references it against 0 known binders and
52 disease associations.
Target properties
| Protein name | C4b-binding protein beta chain |
|---|
| UniProt accession | P20851 |
|---|
| Gene | C4BPB |
|---|
| Organism | Homo sapiens |
|---|
| Length | 252 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (52)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.23
- mean platelet volume · score 0.20
- platelet component distribution width · score 0.11
- acute myeloid leukemia · score 0.10
- reticulocyte count · score 0.10
- reticulocyte measurement · score 0.09
- C4BP measurement · score 0.08
- blood protein measurement · score 0.07
- venous thromboembolism · score 0.06
- Barrett's esophagus · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P20851-F1 | alphafold | PREDICTED | 81.92 | — |
Amino-acid sequence (252 residues)
MFFWCACCLM VAWRVSASDA EHCPELPPVD NSIFVAKEVE GQILGTYVCI KGYHLVGKKT LFCNASKEWD NTTTECRLGH CPDPVLVNGE FSSSGPVNVS DKITFMCNDH YILKGSNRSQ CLEDHTWAPP FPICKSRDCD PPGNPVHGYF EGNNFTLGST ISYYCEDRYY LVGVQEQQCV DGEWSSALPV CKLIQEAPKP ECEKALLAFQ ESKNLCEAME NFMQQLKESG MTMEELKYSL ELKKAELKAK LL
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