About Cytochrome P450 2A7
Cytochrome P450 2A7 (CYP2A7) is a protein
from Homo sapiens identified by UniProt accession
P20853, 494 residues long.
MolForge cross-references it against 0 known binders and
35 disease associations.
Target properties
| Protein name | Cytochrome P450 2A7 |
|---|
| UniProt accession | P20853 |
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| Gene | CYP2A7 |
|---|
| Organism | Homo sapiens |
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| Length | 494 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (35)
Diseases linked to this target (Open Targets).
- cigarettes per day measurement · score 0.32
- neurodegenerative disease · score 0.31
- chronic obstructive pulmonary disease · score 0.29
- hemoglobin measurement · score 0.26
- cutaneous melanoma · score 0.23
- lung adenocarcinoma · score 0.21
- endometrial cancer · score 0.16
- peripheral arterial disease · score 0.15
- nicotine metabolite ratio · score 0.14
- urinary bladder cancer · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P20853-F1 | alphafold | PREDICTED | 95.52 | — |
Amino-acid sequence (494 residues)
MLASGLLLVA LLACLTVMVL MSVWQQRKSR GKLPPGPTPL PFIGNYLQLN TEHICDSIMK FSECYGPVFT IHLGPRRVVV LCGHDAVREA LVDQAEEFSG RGEQATFDWV FKGYGVAFSN GERAKQLLRF AIATLRDFGV GKRGIEERIQ EESGFLIEAI RSTHGANIDP TFFLSRTVSN VISSIVFGDR FDYEDKEFLS LLSMMLGIFQ FTSTSTGQLY EMFSSVMKHL PGPQQQAFKL LQGLEDFIAK KVEHNQRTLD PNSPQDFIDS FLIHMQEEEK NPNTEFYLKN LMMSTLNLFI AGTETVSTTL RYGFLLLMKH PEVEAKVHEE IDRVIGKNRQ PKFEDRTKMP YMEAVIHEIQ RFGDVIPMSL ARRVKKDTKF RDFFLPKGTE VFPMLGSVLR DPSFFSNPQD FNPQHFLDDK GQFKKSDAFV PFSIGKRNCF GEGLARMELF LFFTTVMQNF RLKSSQSPKD IDVSPKHVVF ATIPRNYTMS FLPR
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