About Myelin-associated glycoprotein
Myelin-associated glycoprotein (MAG) is a protein
from Homo sapiens identified by UniProt accession
P20916, 626 residues long.
MolForge cross-references it against 0 known binders and
301 disease associations.
Target properties
| Protein name | Myelin-associated glycoprotein |
|---|
| UniProt accession | P20916 |
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| Gene | MAG |
|---|
| Organism | Homo sapiens |
|---|
| Length | 626 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (301)
Diseases linked to this target (Open Targets).
- Autosomal recessive spastic paraplegia type 75 · score 0.77
- complex hereditary spastic paraplegia · score 0.37
- serum gamma-glutamyl transferase measurement · score 0.19
- genetic disorder · score 0.19
- glioblastoma multiforme · score 0.19
- breast adenocarcinoma · score 0.18
- hereditary spastic paraplegia · score 0.16
- blood phosphate measurement · score 0.12
- head and neck squamous cell carcinoma · score 0.11
- neuropathy · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P20916-F1 | alphafold | PREDICTED | 80.75 | — |
Amino-acid sequence (626 residues)
MIFLTALPLF WIMISASRGG HWGAWMPSSI SAFEGTCVSI PCRFDFPDEL RPAVVHGVWY FNSPYPKNYP PVVFKSRTQV VHESFQGRSR LLGDLGLRNC TLLLSNVSPE LGGKYYFRGD LGGYNQYTFS EHSVLDIVNT PNIVVPPEVV AGTEVEVSCM VPDNCPELRP ELSWLGHEGL GEPAVLGRLR EDEGTWVQVS LLHFVPTREA NGHRLGCQAS FPNTTLQFEG YASMDVKYPP VIVEMNSSVE AIEGSHVSLL CGADSNPPPL LTWMRDGTVL REAVAESLLL ELEEVTPAED GVYACLAENA YGQDNRTVGL SVMYAPWKPT VNGTMVAVEG ETVSILCSTQ SNPDPILTIF KEKQILSTVI YESELQLELP AVSPEDDGEY WCVAENQYGQ RATAFNLSVE FAPVLLLESH CAAARDTVQC LCVVKSNPEP SVAFELPSRN VTVNESEREF VYSERSGLVL TSILTLRGQA QAPPRVICTA RNLYGAKSLE LPFQGAHRLM WAKIGPVGAV VAFAILIAIV CYITQTRRKK NVTESPSFSA GDNPPVLFSS DFRISGAPEK YESERRLGSE RRLLGLRGEP PELDLSYSHS DLGKRPTKDS YTLTEELAEY AEIRVK
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