N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase (AGA)

About N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase

N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase (AGA) is a protein from Homo sapiens identified by UniProt accession P20933, 346 residues long. MolForge cross-references it against 0 known binders and 192 disease associations.

Target properties

Protein name	N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase
UniProt accession	P20933
Gene	AGA
Organism	Homo sapiens
Length	346 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (192)

Diseases linked to this target (Open Targets).

aspartylglucosaminuria · score 0.84
genetic disorder · score 0.49
serum metabolite measurement · score 0.27
asparagine measurement · score 0.27
breast milk measurement · score 0.26
self reported educational attainment · score 0.18
Neurodevelopmental disorder · score 0.12
Intellectual disability · score 0.11
apolipoprotein A 1 measurement · score 0.08
platelet count · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P20933-F1	alphafold	PREDICTED	91.70	—

Amino-acid sequence (346 residues)

MARKSNLPVL LVPFLLCQAL VRCSSPLPLV VNTWPFKNAT EAAWRALASG GSALDAVESG CAMCEREQCD GSVGFGGSPD ELGETTLDAM IMDGTTMDVG AVGDLRRIKN AIGVARKVLE HTTHTLLVGE SATTFAQSMG FINEDLSTTA SQALHSDWLA RNCQPNYWRN VIPDPSKYCG PYKPPGILKQ DIPIHKETED DRGHDTIGMV VIHKTGHIAA GTSTNGIKFK IHGRVGDSPI PGAGAYADDT AGAAAATGNG DILMRFLPSY QAVEYMRRGE DPTIACQKVI SRIQKHFPEF FGAVICANVT GSYGAACNKL STFTQFSFMV YNSEKNQPTE EKVDCI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards