About T-cell surface glycoprotein CD3 zeta chain
T-cell surface glycoprotein CD3 zeta chain (CD247) is a protein
from Homo sapiens identified by UniProt accession
P20963, 164 residues long.
MolForge cross-references it against 0 known binders and
377 disease associations.
Target properties
| Protein name | T-cell surface glycoprotein CD3 zeta chain |
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| UniProt accession | P20963 |
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| Gene | CD247 |
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| Organism | Homo sapiens |
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| Length | 164 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (377)
Diseases linked to this target (Open Targets).
- immunodeficiency 25 · score 0.74
- T-B+ severe combined immunodeficiency due to CD3delta/CD3epsilon/CD3zeta · score 0.69
- cutaneous Leishmaniasis · score 0.58
- blood protein measurement · score 0.51
- asthma · score 0.49
- eosinophil count · score 0.47
- T-B+ severe combined immunodeficiency · score 0.46
- allergic rhinitis · score 0.45
- allergic disease · score 0.43
- Eczematoid dermatitis · score 0.42
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P20963-F1 | alphafold | PREDICTED | 62.40 | — |
Amino-acid sequence (164 residues)
MKWKALFTAA ILQAQLPITE AQSFGLLDPK LCYLLDGILF IYGVILTALF LRVKFSRSAD APAYQQGQNQ LYNELNLGRR EEYDVLDKRR GRDPEMGGKP QRRKNPQEGL YNELQKDKMA EAYSEIGMKG ERRRGKGHDG LYQGLSTATK DTYDALHMQA LPPR
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