Ribose-phosphate pyrophosphokinase 3 (PRPS1L1)

About Ribose-phosphate pyrophosphokinase 3

Ribose-phosphate pyrophosphokinase 3 (PRPS1L1) is a protein from Homo sapiens identified by UniProt accession P21108, 318 residues long. MolForge cross-references it against 0 known binders and 55 disease associations.

Target properties

Protein name	Ribose-phosphate pyrophosphokinase 3
UniProt accession	P21108
Gene	PRPS1L1
Organism	Homo sapiens
Length	318 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (55)

Diseases linked to this target (Open Targets).

PR interval · score 0.32
neurodegenerative disease · score 0.29
body height · score 0.26
Alzheimer disease · score 0.25
multiple sclerosis · score 0.25
Parkinson disease · score 0.25
lysosomal storage disease · score 0.25
neuroinflammatory disorder · score 0.14
basal cell carcinoma · score 0.08
vital capacity · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P21108-F1	alphafold	PREDICTED	94.60	—

Amino-acid sequence (318 residues)

MPNIKIFSGS SHQDLSQKIA DRLGLELGKV VTKKFSNQET CVEIDESVRG EDVYIVQSGC GEINDSLMEL LIMINACKIA SASRVTAVIP CFPYARQDKK DKSRSPISAK LVANMLSIAG ADHIITMDLH ASQIQGFFDI PVDNLYAEPT VLKWIRENIP EWKNCIIVSP DAGGAKRVTS IADQLNVDFA LIHKERKKAN EVDCIVLVGD VNDRVAILVD DMADTCVTIC LAADKLLSAG ATRVYAILTH GIFSGPAISR INTACFEAVV VTNTIPQDEK MKHCSKIRVI DISMILAEAI RRTHNGESVS YLFSHVPL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards