About Uridylate-specific endoribonuclease
Uridylate-specific endoribonuclease (ENDOU) is a protein
from Homo sapiens identified by UniProt accession
P21128, 410 residues long.
MolForge cross-references it against 0 known binders and
85 disease associations.
Target properties
| Protein name | Uridylate-specific endoribonuclease |
|---|
| UniProt accession | P21128 |
|---|
| Gene | ENDOU |
|---|
| Organism | Homo sapiens |
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| Length | 410 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (85)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.20
- brain injury · score 0.14
- age at menarche · score 0.14
- neurofibrillary tangles measurement · score 0.11
- retinitis pigmentosa · score 0.11
- optic disc size measurement · score 0.10
- age-related macular degeneration · score 0.09
- X-linked retinal dysplasia · score 0.08
- agoraphobia · score 0.08
- Progressive cone dystrophy · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P21128-F1 | alphafold | PREDICTED | 85.37 | — |
Amino-acid sequence (410 residues)
MRACISLVLA VLCGLAWAGK IESCASRCNE KFNRDAACQC DRRCLWHGNC CEDYEHLCTE DHKESEPLPQ LEEETEEALA SNLYSAPTSC QGRCYEAFDK HHQCHCNARC QEFGNCCKDF ESLCSDHEVS HSSDAITKEE IQSISEKIYR ADTNKAQKED IVLNSQNCIS PSETRNQVDR CPKPLFTYVN EKLFSKPTYA AFINLLNNYQ RATGHGEHFS AQELAEQDAF LREIMKTAVM KELYSFLHHQ NRYGSEQEFV DDLKNMWFGL YSRGNEEGDS SGFEHVFSGE VKKGKVTGFH NWIRFYLEEK EGLVDYYSHI YDGPWDSYPD VLAMQFNWDG YYKEVGSAFI GSSPEFEFAL YSLCFIARPG KVCQLSLGGY PLAVRTYTWD KSTYGNGKKY IATAYIVSST
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