About Pleiotrophin
Pleiotrophin (PTN) is a protein
from Homo sapiens identified by UniProt accession
P21246, 168 residues long.
MolForge cross-references it against 0 known binders and
260 disease associations.
Target properties
| Protein name | Pleiotrophin |
|---|
| UniProt accession | P21246 |
|---|
| Gene | PTN |
|---|
| Organism | Homo sapiens |
|---|
| Length | 168 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (260)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.38
- hypertension · score 0.28
- risk-taking behaviour · score 0.26
- schizophrenia · score 0.26
- insomnia measurement · score 0.26
- self reported educational attainment · score 0.22
- neuroticism measurement · score 0.20
- cortical surface area measurement · score 0.18
- brain measurement · score 0.17
- attention deficit hyperactivity disorder · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P21246-F1 | alphafold | PREDICTED | 75.06 | — |
Amino-acid sequence (168 residues)
MQAQQYQQQR RKFAAAFLAF IFILAAVDTA EAGKKEKPEK KVKKSDCGEW QWSVCVPTSG DCGLGTREGT RTGAECKQTM KTQRCKIPCN WKKQFGAECK YQFQAWGECD LNTALKTRTG SLKRALHNAE CQKTVTISKP CGKLTKPKPQ AESKKKKKEG KKQEKMLD
Explore Pleiotrophin with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets