About V-type proton ATPase subunit B, brain isoform
V-type proton ATPase subunit B, brain isoform (ATP6V1B2) is a protein
from Homo sapiens identified by UniProt accession
P21281, 511 residues long.
MolForge cross-references it against 0 known binders and
133 disease associations.
Target properties
| Protein name | V-type proton ATPase subunit B, brain isoform |
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| UniProt accession | P21281 |
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| Gene | ATP6V1B2 |
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| Organism | Homo sapiens |
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| Length | 511 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (133)
Diseases linked to this target (Open Targets).
- Zimmermann-Laband syndrome 2 · score 0.63
- Autosomal dominant deafness-onychodystrophy syndrome · score 0.62
- Zimmermann-Laband syndrome · score 0.62
- neurodegenerative disease · score 0.57
- Alzheimer disease · score 0.52
- Parkinson disease · score 0.52
- multiple sclerosis · score 0.52
- lysosomal storage disease · score 0.52
- autosomal dominant deafness - onychodystrophy syndrome · score 0.48
- DOORS syndrome · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P21281-F1 | alphafold | PREDICTED | 86.03 | — |
Amino-acid sequence (511 residues)
MALRAMRGIV NGAAPELPVP TGGPAVGARE QALAVSRNYL SQPRLTYKTV SGVNGPLVIL DHVKFPRYAE IVHLTLPDGT KRSGQVLEVS GSKAVVQVFE GTSGIDAKKT SCEFTGDILR TPVSEDMLGR VFNGSGKPID RGPVVLAEDF LDIMGQPINP QCRIYPEEMI QTGISAIDGM NSIARGQKIP IFSAAGLPHN EIAAQICRQA GLVKKSKDVV DYSEENFAIV FAAMGVNMET ARFFKSDFEE NGSMDNVCLF LNLANDPTIE RIITPRLALT TAEFLAYQCE KHVLVILTDM SSYAEALREV SAAREEVPGR RGFPGYMYTD LATIYERAGR VEGRNGSITQ IPILTMPNDD ITHPIPDLTG YITEGQIYVD RQLHNRQIYP PINVLPSLSR LMKSAIGEGM TRKDHADVSN QLYACYAIGK DVQAMKAVVG EEALTSDDLL YLEFLQKFER NFIAQGPYEN RTVFETLDIG WQLLRIFPKE MLKRIPQSTL SEFYPRDSAK H
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