Sphingosine 1-phosphate receptor 1 (S1PR1)

About Sphingosine 1-phosphate receptor 1

Sphingosine 1-phosphate receptor 1 (S1PR1) is a protein from Homo sapiens identified by UniProt accession P21453, 382 residues long. MolForge cross-references it against 0 known binders and 484 disease associations.

Target properties

Protein name	Sphingosine 1-phosphate receptor 1
UniProt accession	P21453
Gene	S1PR1
Organism	Homo sapiens
Length	382 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (5)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (484)

Diseases linked to this target (Open Targets).

multiple sclerosis · score 0.60
relapsing-remitting multiple sclerosis · score 0.60
ulcerative colitis · score 0.59
lymphocyte count · score 0.53
immune system disease · score 0.53
lymphocyte percentage of leukocytes · score 0.47
chronic progressive multiple sclerosis · score 0.47
neutrophil percentage of leukocytes · score 0.45
eosinophil count · score 0.45
secondary progressive multiple sclerosis · score 0.44

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P21453-F1	alphafold	PREDICTED	81.00	—

Amino-acid sequence (382 residues)

MGPTSVPLVK AHRSSVSDYV NYDIIVRHYN YTGKLNISAD KENSIKLTSV VFILICCFII LENIFVLLTI WKTKKFHRPM YYFIGNLALS DLLAGVAYTA NLLLSGATTY KLTPAQWFLR EGSMFVALSA SVFSLLAIAI ERYITMLKMK LHNGSNNFRL FLLISACWVI SLILGGLPIM GWNCISALSS CSTVLPLYHK HYILFCTTVF TLLLLSIVIL YCRIYSLVRT RSRRLTFRKN ISKASRSSEK SLALLKTVII VLSVFIACWA PLFILLLLDV GCKVKTCDIL FRAEYFLVLA VLNSGTNPII YTLTNKEMRR AFIRIMSCCK CPSGDSAGKF KRPIIAGMEF SRSKSDNSSH PQKDEGDNPE TIMSSGNVNS SS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards