About Kit ligand
Kit ligand (KITLG) is a protein
from Homo sapiens identified by UniProt accession
P21583, 273 residues long.
MolForge cross-references it against 0 known binders and
1,157 disease associations.
Target properties
| Protein name | Kit ligand |
|---|
| UniProt accession | P21583 |
|---|
| Gene | KITLG |
|---|
| Organism | Homo sapiens |
|---|
| Length | 273 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (1157)
Diseases linked to this target (Open Targets).
- Waardenburg syndrome, IIa 2F · score 0.66
- hyperpigmentation with or without hypopigmentation, familial progressive · score 0.65
- autosomal dominant nonsyndromic hearing loss 69 · score 0.58
- mean corpuscular volume · score 0.49
- hair color · score 0.48
- testicular carcinoma · score 0.47
- deafness · score 0.47
- familial progressive hyper- and hypopigmentation · score 0.46
- leukocyte count · score 0.45
- mean corpuscular hemoglobin concentration · score 0.43
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P21583-F1 | alphafold | PREDICTED | 71.86 | — |
Amino-acid sequence (273 residues)
MKKTQTWILT CIYLQLLLFN PLVKTEGICR NRVTNNVKDV TKLVANLPKD YMITLKYVPG MDVLPSHCWI SEMVVQLSDS LTDLLDKFSN ISEGLSNYSI IDKLVNIVDD LVECVKENSS KDLKKSFKSP EPRLFTPEEF FRIFNRSIDA FKDFVVASET SDCVVSSTLS PEKDSRVSVT KPFMLPPVAA SSLRNDSSSS NRKAKNPPGD SSLHWAAMAL PALFSLIIGF AFGALYWKKR QPSLTRAVEN IQINEEDNEI SMLQEKEREF QEV
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