5'-nucleotidase (NT5E)

About 5'-nucleotidase

5'-nucleotidase (NT5E) is a protein from Homo sapiens identified by UniProt accession P21589, 574 residues long. MolForge cross-references it against 0 known binders and 587 disease associations.

Target properties

Protein name	5'-nucleotidase
UniProt accession	P21589
Gene	NT5E
Organism	Homo sapiens
Length	574 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (587)

Diseases linked to this target (Open Targets).

hereditary arterial and articular multiple calcification syndrome · score 0.59
serum metabolite measurement · score 0.43
non-small cell lung carcinoma · score 0.32
heel bone mineral density · score 0.32
blood metabolite measurement · score 0.29
metabolite measurement · score 0.29
body height · score 0.26
cutaneous melanoma · score 0.25
genetic disorder · score 0.19
balding measurement · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P21589-F1	alphafold	PREDICTED	91.88	—

Amino-acid sequence (574 residues)

MCPRAARAPA TLLLALGAVL WPAAGAWELT ILHTNDVHSR LEQTSEDSSK CVNASRCMGG VARLFTKVQQ IRRAEPNVLL LDAGDQYQGT IWFTVYKGAE VAHFMNALRY DAMALGNHEF DNGVEGLIEP LLKEAKFPIL SANIKAKGPL ASQISGLYLP YKVLPVGDEV VGIVGYTSKE TPFLSNPGTN LVFEDEITAL QPEVDKLKTL NVNKIIALGH SGFEMDKLIA QKVRGVDVVV GGHSNTFLYT GNPPSKEVPA GKYPFIVTSD DGRKVPVVQA YAFGKYLGYL KIEFDERGNV ISSHGNPILL NSSIPEDPSI KADINKWRIK LDNYSTQELG KTIVYLDGSS QSCRFRECNM GNLICDAMIN NNLRHTDEMF WNHVSMCILN GGGIRSPIDE RNNGTITWEN LAAVLPFGGT FDLVQLKGST LKKAFEHSVH RYGQSTGEFL QVGGIHVVYD LSRKPGDRVV KLDVLCTKCR VPSYDPLKMD EVYKVILPNF LANGGDGFQM IKDELLRHDS GDQDINVVST YISKMKVIYP AVEGRIKFST GSHCHGSFSL IFLSLWAVIF VLYQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards