About Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic (GPD1) is a protein
from Homo sapiens identified by UniProt accession
P21695, 349 residues long.
MolForge cross-references it against 0 known binders and
139 disease associations.
Target properties
| Protein name | Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic |
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| UniProt accession | P21695 |
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| Gene | GPD1 |
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| Organism | Homo sapiens |
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| Length | 349 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (139)
Diseases linked to this target (Open Targets).
- transient infantile hypertriglyceridemia and hepatosteatosis · score 0.77
- neurodegenerative disease · score 0.44
- genetic disorder · score 0.34
- breast adenocarcinoma · score 0.18
- hypertension · score 0.12
- diastolic blood pressure · score 0.11
- systolic blood pressure · score 0.10
- neoplasm · score 0.09
- lymphocyte count · score 0.08
- urinary bladder carcinoma · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P21695-F1 | alphafold | PREDICTED | 96.39 | — |
Amino-acid sequence (349 residues)
MASKKVCIVG SGNWGSAIAK IVGGNAAQLA QFDPRVTMWV FEEDIGGKKL TEIINTQHEN VKYLPGHKLP PNVVAVPDVV QAAEDADILI FVVPHQFIGK ICDQLKGHLK ANATGISLIK GVDEGPNGLK LISEVIGERL GIPMSVLMGA NIASEVADEK FCETTIGCKD PAQGQLLKEL MQTPNFRITV VQEVDTVEIC GALKNVVAVG AGFCDGLGFG DNTKAAVIRL GLMEMIAFAK LFCSGPVSSA TFLESCGVAD LITTCYGGRN RKVAEAFART GKSIEQLEKE LLNGQKLQGP ETARELYSIL QHKGLVDKFP LFMAVYKVCY EGQPVGEFIH CLQNHPEHM
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