C5a anaphylatoxin chemotactic receptor 1 (C5AR1)

About C5a anaphylatoxin chemotactic receptor 1

C5a anaphylatoxin chemotactic receptor 1 (C5AR1) is a protein from Homo sapiens identified by UniProt accession P21730, 350 residues long. MolForge cross-references it against 0 known binders and 499 disease associations.

Target properties

Protein name	C5a anaphylatoxin chemotactic receptor 1
UniProt accession	P21730
Gene	C5AR1
Organism	Homo sapiens
Length	350 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (499)

Diseases linked to this target (Open Targets).

anti-neutrophil cytoplasmic antibody-associated vasculitis · score 0.47
Granulomatosis with Polyangiitis · score 0.46
microscopic polyangiitis · score 0.46
immune system disease · score 0.37
anti-neutrophil antibody associated vasculitis · score 0.29
vasculitis · score 0.28
glioblastoma multiforme · score 0.27
ovarian cancer · score 0.25
breast adenocarcinoma · score 0.17
head and neck squamous cell carcinoma · score 0.16

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P21730-F1	alphafold	PREDICTED	85.73	—

Amino-acid sequence (350 residues)

MDSFNYTTPD YGHYDDKDTL DLNTPVDKTS NTLRVPDILA LVIFAVVFLV GVLGNALVVW VTAFEAKRTI NAIWFLNLAV ADFLSCLALP ILFTSIVQHH HWPFGGAACS ILPSLILLNM YASILLLATI SADRFLLVFK PIWCQNFRGA GLAWIACAVA WGLALLLTIP SFLYRVVREE YFPPKVLCGV DYSHDKRRER AVAIVRLVLG FLWPLLTLTI CYTFILLRTW SRRATRSTKT LKVVVAVVAS FFIFWLPYQV TGIMMSFLEP SSPTFLLLKK LDSLCVSFAY INCCINPIIY VVAGQGFQGR LRKSLPSLLR NVLTEESVVR ESKSFTRSTV DTMAQKTQAV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards