Midkine (MDK)

About Midkine

Midkine (MDK) is a protein from Homo sapiens identified by UniProt accession P21741, 143 residues long. MolForge cross-references it against 0 known binders and 438 disease associations.

Target properties

Protein name	Midkine
UniProt accession	P21741
Gene	MDK
Organism	Homo sapiens
Length	143 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (438)

Diseases linked to this target (Open Targets).

hepatocellular carcinoma · score 0.13
glioblastoma multiforme · score 0.11
neoplasm · score 0.11
cancer · score 0.10
Systemic lupus erythematosus · score 0.10
non-small cell lung carcinoma · score 0.10
oral squamous cell carcinoma · score 0.10
head and neck squamous cell carcinoma · score 0.09
Sepsis · score 0.09
immature platelet fraction · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P21741-F1	alphafold	PREDICTED	72.43	—

Amino-acid sequence (143 residues)

MQHRGFLLLT LLALLALTSA VAKKKDKVKK GGPGSECAEW AWGPCTPSSK DCGVGFREGT CGAQTQRIRC RVPCNWKKEF GADCKYKFEN WGACDGGTGT KVRQGTLKKA RYNAQCQETI RVTKPCTPKT KAKAKAKKGK GKD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards