Zona pellucida sperm-binding protein 3 (ZP3)

About Zona pellucida sperm-binding protein 3

Zona pellucida sperm-binding protein 3 (ZP3) is a protein from Homo sapiens identified by UniProt accession P21754, 424 residues long. MolForge cross-references it against 0 known binders and 124 disease associations.

Target properties

Protein name	Zona pellucida sperm-binding protein 3
UniProt accession	P21754
Gene	ZP3
Organism	Homo sapiens
Length	424 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (124)

Diseases linked to this target (Open Targets).

female infertility due to zona pellucida defect · score 0.55
Empty ovarian follicle · score 0.34
triglyceride measurement · score 0.26
lung adenocarcinoma · score 0.25
cutaneous melanoma · score 0.25
blood protein measurement · score 0.17
breast adenocarcinoma · score 0.16
glioblastoma multiforme · score 0.15
head and neck squamous cell carcinoma · score 0.13
cancer · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P21754-F1	alphafold	PREDICTED	77.73	—

Amino-acid sequence (424 residues)

MELSYRLFIC LLLWGSTELC YPQPLWLLQG GASHPETSVQ PVLVECQEAT LMVMVSKDLF GTGKLIRAAD LTLGPEACEP LVSMDTEDVV RFEVGLHECG NSMQVTDDAL VYSTFLLHDP RPVGNLSIVR TNRAEIPIEC RYPRQGNVSS QAILPTWLPF RTTVFSEEKL TFSLRLMEEN WNAEKRSPTF HLGDAAHLQA EIHTGSHVPL RLFVDHCVAT PTPDQNASPY HTIVDFHGCL VDGLTDASSA FKVPRPGPDT LQFTVDVFHF ANDSRNMIYI TCHLKVTLAE QDPDELNKAC SFSKPSNSWF PVEGSADICQ CCNKGDCGTP SHSRRQPHVM SQWSRSASRN RRHVTEEADV TVGPLIFLDR RGDHEVEQWA LPSDTSVVLL GVGLAVVVSL TLTAVILVLT RRCRTASHPV SASE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards