Macrophage scavenger receptor types I and II (MSR1)

About Macrophage scavenger receptor types I and II

Macrophage scavenger receptor types I and II (MSR1) is a protein from Homo sapiens identified by UniProt accession P21757, 451 residues long. MolForge cross-references it against 0 known binders and 286 disease associations.

Target properties

Protein name	Macrophage scavenger receptor types I and II
UniProt accession	P21757
Gene	MSR1
Organism	Homo sapiens
Length	451 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (286)

Diseases linked to this target (Open Targets).

IGF-1 measurement · score 0.49
Barrett's esophagus · score 0.41
Familial prostate cancer · score 0.41
prostate carcinoma · score 0.41
galectin-3-binding protein measurement · score 0.40
ovarian cancer · score 0.39
prostate adenocarcinoma · score 0.37
familial prostate carcinoma · score 0.37
protein measurement · score 0.36
esophageal adenocarcinoma · score 0.34

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P21757-F1	alphafold	PREDICTED	67.41	—

Amino-acid sequence (451 residues)

MEQWDHFHNQ QEDTDSCSES VKFDARSMTA LLPPNPKNSP SLQEKLKSFK AALIALYLLV FAVLIPLIGI VAAQLLKWET KNCSVSSTNA NDITQSLTGK GNDSEEEMRF QEVFMEHMSN MEKRIQHILD MEANLMDTEH FQNFSMTTDQ RFNDILLQLS TLFSSVQGHG NAIDEISKSL ISLNTTLLDL QLNIENLNGK IQENTFKQQE EISKLEERVY NVSAEIMAMK EEQVHLEQEI KGEVKVLNNI TNDLRLKDWE HSQTLRNITL IQGPPGPPGE KGDRGPTGES GPRGFPGPIG PPGLKGDRGA IGFPGSRGLP GYAGRPGNSG PKGQKGEKGS GNTLTPFTKV RLVGGSGPHE GRVEILHSGQ WGTICDDRWE VRVGQVVCRS LGYPGVQAVH KAAHFGQGTG PIWLNEVFCF GRESSIEECK IRQWGTRACS HSEDAGVTCT L

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards