Non-selective voltage-gated ion channel VDAC1 (VDAC1)

About Non-selective voltage-gated ion channel VDAC1

Non-selective voltage-gated ion channel VDAC1 (VDAC1) is a protein from Homo sapiens identified by UniProt accession P21796, 283 residues long. MolForge cross-references it against 0 known binders and 366 disease associations.

Target properties

Protein name	Non-selective voltage-gated ion channel VDAC1
UniProt accession	P21796
Gene	VDAC1
Organism	Homo sapiens
Length	283 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (366)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.51
cup-to-disc ratio measurement · score 0.35
neuroinflammatory disorder · score 0.33
glioblastoma multiforme · score 0.24
neoplasm · score 0.11
cancer · score 0.11
breast cancer · score 0.10
non-small cell lung carcinoma · score 0.09
melanoma · score 0.08
acute kidney failure · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P21796-F1	alphafold	PREDICTED	93.07	—

Amino-acid sequence (283 residues)

MAVPPTYADL GKSARDVFTK GYGFGLIKLD LKTKSENGLE FTSSGSANTE TTKVTGSLET KYRWTEYGLT FTEKWNTDNT LGTEITVEDQ LARGLKLTFD SSFSPNTGKK NAKIKTGYKR EHINLGCDMD FDIAGPSIRG ALVLGYEGWL AGYQMNFETA KSRVTQSNFA VGYKTDEFQL HTNVNDGTEF GGSIYQKVNK KLETAVNLAW TAGNSNTRFG IAAKYQIDPD ACFSAKVNNS SLIGLGYTQT LKPGIKLTLS ALLDGKNVNA GGHKLGLGLE FQA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards