Biglycan (BGN)

About Biglycan

Biglycan (BGN) is a protein from Homo sapiens identified by UniProt accession P21810, 368 residues long. MolForge cross-references it against 0 known binders and 484 disease associations.

Target properties

Protein name	Biglycan
UniProt accession	P21810
Gene	BGN
Organism	Homo sapiens
Length	368 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (484)

Diseases linked to this target (Open Targets).

X-linked spondyloepimetaphyseal dysplasia · score 0.74
familial thoracic aortic aneurysm and aortic dissection · score 0.65
Rare disease with thoracic aortic aneurysm and aortic dissection · score 0.47
Familial hemophagocytic lymphohistiocytosis · score 0.27
breast adenocarcinoma · score 0.22
cutaneous melanoma · score 0.20
Abnormality of the cardiovascular system · score 0.19
thyroid gland adenocarcinoma · score 0.18
gastric adenocarcinoma · score 0.15
neoplasm · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P21810-F1	alphafold	PREDICTED	85.59	—

Amino-acid sequence (368 residues)

MWPLWRLVSL LALSQALPFE QRGFWDFTLD DGPFMMNDEE ASGADTSGVL DPDSVTPTYS AMCPFGCHCH LRVVQCSDLG LKSVPKEISP DTTLLDLQNN DISELRKDDF KGLQHLYALV LVNNKISKIH EKAFSPLRKL QKLYISKNHL VEIPPNLPSS LVELRIHDNR IRKVPKGVFS GLRNMNCIEM GGNPLENSGF EPGAFDGLKL NYLRISEAKL TGIPKDLPET LNELHLDHNK IQAIELEDLL RYSKLYRLGL GHNQIRMIEN GSLSFLPTLR ELHLDNNKLA RVPSGLPDLK LLQVVYLHSN NITKVGVNDF CPMGFGVKRA YYNGISLFNN PVPYWEVQPA TFRCVTDRLA IQFGNYKK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards